Triz-EDTA Ear Cleaning Solutions

Triz-EDTA Ear Drops


What is Triz-EDTA?

Triz-EDTA solution is an ear cleaner used in dogs and cats.  It is primarily used as adjunct therapy for the treatment of ear infections such as otitis (inflammation of the ear) and particularly those infections caused by gram negative bacteria.

What is in Triz-EDTA ear drops?

The solution contains typically contains two ingredients.  EDTA which chelates metal ions, such as calcium and magnesium,  These ions are necessary to maintain the integrity of the cell membrane or cell wall of bacteria. The EDTA makes the cell membrane become porous so that antibiotics can diffuse easily into the bacteria and terminate the infection. T

The solution also contains a Triz buffer which keeps the ear canal at an optimum pH for many antibiotics such as aminoglycosides and fluoroquinolones.

In addition, too its chelating effect and ability to weaken the cell wall of gram negative bacteria, Triz-EDTA ear drop solution can also inactivate the Pseudomonas efflux pumps of bacteria. Efflux pumps cause antibiotics to be actively pumped out of the bacteria.  This is a common mechanism for causing the development of antibiotic resistance.  By inactivating the efflux pumps, the sensitivity to antibiotic is improved.

What can Triz-EDTA solution be used for?

Clinically, Triz-EDTA solution is used as cleaning agent and/or pre-treatment solution.  Specifically, it may be used before antibacterial medication is applied or in conjunction with anti-biotic solutions

Triz-EDTA solution may also be used as a flushing agent. It is safe to use and can be used to flush the bulla in cases of otitis media (inflammation of the inner ear).  Subsidiary uses also include a flushing agent for multiple organ systems (urogenital, skin, bladder, trachea, etc.).  However, depending on the site there may be issue of sterility.  If you are considering using it for an alternative internal system, you should check with the Bova Pharmacists for further advice

What are the specific indications?

Triz-EDTA alone has been shown in vitro to have potent bactericidal effects. Used as a lavage, Triz-EDTA has been shown to be effective against otitis externa caused by Bacillus spp., Staphylococcus aureus, Candida spp., Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, Trichosporon spp., and Streptococcus spp. with no adverse effects.

Triz-EDTA can also be used for preventing the recurrence of ear infections caused by Pseudomonas and other bacteria by using it as part of a regular ear cleaning regimen. It can be particularly useful for dogs which are predisposed to recurrent otitis (e.g. dogs with chronic disease like atopy, idiopathic seborrhea).


  • * Triz-EDTA Ear Drop Solution may be used for long term prevention of recurrent infection as a drop or as a pre-treatment soak   before administering antibiotics like enrofloxacin (baytril)
  • * It is safe to use in ruptured ear drums and middle ear infections
  • * It is not acidic and creates an alkaline pH
  • * The active ingredients stops :
  •       (1) Pseudomonas efflux pumps
  •       (2) nhibits ulcerating bacterial enzymes
  •       (3)Weakens gram negative cell walls
  •       (4) May be used in multiple organ systems but speak to your Bova Pharmacist for further advice

Alexander Corry

Chief Pharmacist

Bova Compounding